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Interdisciplinary Division of Neuro-Oncology

The Interdisciplinary Division of Neuro-Oncology at the Hertie-Institut for Clinical Brain Research is the result of the, in the context of the Excellent Initiative, newly created W3-Professorship in Neuro-Oncology at the Eberhard-Karls-University Tübingen. This Division has been established at the University Hospital Tübingen (UKT) and is affiliated to the Centre of Neurology (Department Prof. Ziemann) and the Department of Neurosurgery (Prof. Dr. M. Tatagiba) in cooperation with the Department of Radio-Oncology (Prof. Dr. D. Zips). Out-patient and in-patient treatment of neuro-oncologycal patients is organised on an interdisciplinary basis under the umbrella of the Centre for Neuro-Oncology at the Comprehensive Cancer Center Tübingen-Stuttgart.


The projects of the lab are focusing on the biology of brain tumors, especially with targeted individualized therapies, molecular mechanisms in the development of resistance and cell based therapy approaches.


The research team is supported by the German Scholars Organisation and the Else Kröner-Fresenius Stiftung.

Outpatient clinic

Selected publications


Niessner H, Schmitz J, Tabatabai G, Schmid A, Calaminus C, Sinnberg T, Weide B, Eigentler TK, Garbe C, Schittek B, Quintanilla-Fend L, Bender B, Mai M, Praetorius C, Beissert S, Schackert G, Muders M, Meinhardt M, Baretton GB, Dummer R, Flaherty KT, Pichler BJ, Kulms D, Westphal D, Meier F. PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo. Clin Cancer Res. 2016. [Epub ahead of print]


Skardelly M, Brendle E, Noell S, Behling F, Wuttke TV, Schittenhelm J, Bisdas S, Meisner C, Rona S, Tatagiba MS, Tabatabai G. Predictors of preoperative and early postoperative seizures in patients with intra-axial primary and metastatic brain tumors: A retrospective observational single center study. Ann Neurol. 2015;78(6):917-28.


Weller M, Tabatabai G, Kästner B, Felsberg J, Steinbach JP, Wick A, Schnell O, Hau P, Herrlinger U, Sabel MC, Wirsching HG, Ketter R, Bähr O, Platten M, Tonn JC, Schlegel U, Marosi C, Goldbrunner R, Stupp R, Homicsko K, Pichler J, Nikkhah G, Meixensberger J, Vajkoczy P, Kollias S, Hüsing J, Reifenberger G, Wick W; DIRECTOR Study Group. MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial. Clin Cancer Res. 2015 May 1;21(9):2057-64. doi: 10.1158/1078-0432.CCR-14-2737. Epub 2015 Feb 5.


Wirsching HG, Krishnan S, Florea AM, Frei K, Hasenbach K, Reifenberger G, Krayenbuehl N, Weller M, Tabatabai G. Thymosin β4 gene silencing decreases stemness and invasiveness in glioblastoma. Brain 2014;137:433-48 


Gulbins E, Palmada M, Reichl M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal B, Staedtler S, Ackerman TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassme H, Kornhuber J. Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med 2013;19:934-938 


Gramatzki D, Herrmann C, Happold C, Becker KA, Gulbins E, Weller M, Tabatabai G. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PLoS One 2013; 7;8(5):e63527


Spescha RD, Shi Y, Wegener S, Keller S, Weber B, Wyss MM, Lauinger N, Tabatabai G, Paneni F, Consentino F, Hock C, Weller M, Nitsch RM, Lüscher TF, Camici GG. Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury. Eur Heart J. 2013; 34: 96-103 


Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G, Simon M, Nikkhah G, Papsdorf K, Steinbach JP, Sabel M, Combs SE, Vesper J, Braun C, Meixensberger J, Ketter R, Mayer-Steinacker R, Reifenberger G, Weller M. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomized, phase 3 trial. Lancet Oncol 2012; 13:707-715 


Hasenbach K, Wiehr S, Herrmann C, Mannheim J, Cay F, von Kürthy G, Bolmont T, Grathwohl SA, Weller M, Lengerke C, Pichler B, Tabatabai G. Monitoring the glioma tropism of bone marrow-derived progenitor cells by two-photon laser scanning microscopy and positron emission tomography. Neuro Oncol 2012; 12:302-307 


Schraivogel D, Weinmann L, Beier D, Tabatabai G, Eichner A, Zhu JY, Anton M, Sixt M, Weller M, Beier CP, Meister G. CAMTA is a novel tumor suppressor regulated by miR-9/9* in glioblastoma cells. EMBO J 2011; 30, 4309-4322

Research Group



Neuro-Oncological Outpatient Clinic


The neurological and neurosurgical Neuro-Oncological Outpatient Clinic have been united by the Interdisciplinary Division Neuro-Oncology under the roof of the Centre for Neuro-Oncology at the Southwest German Cancer Centre. The range of service of the Outpatient Clinic includes the pre-and post-operative consultations, care and treatment of the patients with neuro-oncological tumors.










Consultation hours, contact persons and further information can be found on the page of the Neuro-Oncological Outpatient Clinic of the University Hospital Tübingen.

Research group leader
Prof. Dr. Dr. Ghazaleh Tabatabai Address

Center of Neurology
Hertie Institute for Clinical Brain Research
Department Neurology and Stroke

Otfried-Müller-Straße 27
72076 Tübingen

Phone: +49 (0)7071 29-85018
Fax: +49 (0)7071 29-5957